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DePuy Synthes | J&J Medical Devices Skip to main content Healthcare Professional View HCP Navigation Home Companies Back Acclarent Biosense Webster CERENOVUS DePuy Synthes Ethicon Mentor Sterilmed Products Back All Products Access Adjunctive Hemostats Airway Balloon Dilation System Balloon Sinuplasty Breast Augmentation Breast Reconstruction CMF Energy Sealing & Dissecting Eustachian Tube Balloon Dilation System Foot & Ankle Hernia Mesh & Fixation Hip Joint Reconstruction Knee Ligation Magnetic Sphincter Augmentation Microwave Ablation Nasal Dilation System Navigation Power Tools Shoulder Sinus Surgeries Spine Sports Medicine Surgical Stapling Trauma Uterine & Pelvic Vascular Access & Infection Control Wound Closure Specialties & Procedures Back Specialties Procedures Services Back CareAdvantage CareSense Cleaning & Sterilization Healthy Workforce Hip Fracture Care Program Infection Risk Management Loaner Program MatrixRIB™ Care Program Mentor New Practice Program Mentor Warranty Information Outpatient Pathways Outpatient Solutions Perioperative Efficiency Reprocessing Sustainability Supply Chain Optimization News Support Back ASR Recall Contact California Compliance Contributions & Donations Education Grants Ethicon Product Center (EPC) Exhibits & Sponsorships Fellowships IFU Library Investigator-Initiated Studies J&J Institute J&J Innovation Center Legal Medical Information Requests (MIR) Reimbursement About Us Back About Us Business Conduct Annual Reports Corporate Responsibility Credo Info for Investors J&J Careers Leadership Team/Executive Bios Policies & Statements Toggle navigation J&J Privacy Notice Change Location Continue We use cookies on this site to enhance your user experience. This site uses cookies as described in our Cookie Policy . To see what cookies we serve and set your own preferences, please check our cookie settings panel. Otherwise, if you agree to our use of cookies and legal notice, you can continue to use our site. Search We are inspired by the opportunity to work together to advance patient care. Working together, we can deliver innovative solutions to today's healthcare challenges to advance patient care and deliver clinical and economic value to healthcare systems throughout the world. For Healthcare Professionals For Patients DePuy Synthes Companies Who We Are Our History Social Responsibility The DePuy Synthes Companies are part of the Johnson & Johnson Family of Companies. We offer one of the world’s most comprehensive portfolios of orthopaedic products and services in the areas of joint reconstruction, trauma, spine, sports medicine, cranio-maxillofacial, power tools and biomaterials. Today, DePuy Synthes Companies employs approximately 18,000 people across 60 countries and generates $10 billion in annual sales. Most importantly, its deep and broad portfolio supports nearly one million orthopaedic procedures worldwide annually. And it all began with a splint. DePuy Synthes Companies has a very rich history – a history of innovation, of working with some of the greatest minds in the industry and of making a difference in the lives of tens of millions of patients around the world. And it all began with a splint. Back in 1895, a 35-year-old chemist and pharmaceutical salesman named Revra DePuy came up with the idea of starting a business to manufacture fiber splints that could be customized to fit patients and would be an advance over the wooden splints that were commonly used in the late nineteenth century. DePuy opened his business, which he named DePuy Manufacturing Company, in a hotel room in downtown Warsaw, a city in northern Indiana that is home to several natural lakes and which DePuy had grown fond of during his work-related travels. Even before Revra DePuy made his first sale, he made history. His business became the first orthopaedic manufacturing business in the world, and his decision to set up shop in Warsaw was the catalyst for Warsaw becoming the “Orthopaedic Capital of the World.®” Over the next quarter century, until his death in 1921, Revra DePuy continued to make splints and grow his business. He replaced his fiber splints with wire cloth splints. He added more than a dozen employees to the payroll. He also complemented his mail-order business with a small team of salesmen, one of whom was Justin Zimmer, who later started his own splint manufacturing company in Warsaw. In the decades following Revra DePuy’s death, the orthopaedics industry changed dramatically. New scientific advances led to the development of artificial joints, as well as techniques for correcting spinal deformities, repairing broken bones with internal fixation devices and many other innovations. DePuy Manufacturing not only adapted to the changing orthopaedic industry, it helped shape it. Through a series of leaders, owners, acquisitions, collaborations and joint ventures, DePuy Manufacturing transformed from a company that made splints to a leader in developing and manufacturing implants and instruments to treat a wide range of diseases and disorders of the musculoskeletal and neurological systems. Along the way, there were many company “firsts.” DePuy introduced the first mobile bearing knee system in the United States, the LCS® Knee System. It pioneered POROCOAT® Porous Coating, which is composed of sintered alloy beads that allow biological fixation to bone without the use of bone cement. During the 1980’s, DePuy’s AML® Hip System became the first cementless porous-coated implant indicated for biological fixation in the world. Innovation and growth were further fueled by several mergers and acquisitions. In 1990, DePuy’s parent company at the time acquired Chas. F. Thackray Limited (Leeds, United Kingdom). Thackray played a key role in the development of cemented fixation through its work with Sir John Charnley, the “father” of total hip replacement. DePuy’s work in biologic fixation and Thackray’s contributions to cemented fixation continue to shape new innovations to this day. Interestingly, not only did DePuy go on to manufacture and market the CHARNLEY Hip for many years , it also had marketing rights for some time to the Müller® Hip, named after Swiss orthopaedic surgeon Maurice E. Müller, whose cemented straight stem has remained virtually unchanged since its inception decades ago. In 1998, Johnson & Johnson, one of the world’s largest healthcare companies, acquired DePuy, by then known as DePuy, Inc. Later, in 2012, Johnson & Johnson acquired global medical device company Synthes, Inc., and combined that company with the DePuy franchise to create one of the world’s largest orthopaedic and neurological businesses. We are inspired to be good citizens of the world. We are responsible to the communities in which we live and work and to the world community. We must be good citizens. We must encourage civic improvements, and better health and education. We must maintain the property we are privileged to use, protecting the environment and natural resources. The Environment As a medical device manufacturer, DePuy Synthes Companies is mindful of our influence and our impact on the environment. Our LeLocle, Switzerland facility has significantly reduced its usage of volatile organic compounds (VOCs) by replacing traditional degreasing methods that used VOCs with a water-based cleaning method. We have made strides in packaging improvements as well. Our Warsaw, Indiana facility has nearly eliminated the use of PVC in all Warsaw-based packaging. Our Blackpool, England facility has implemented the use of Electronic IFUs (Instructions for Use) for a range of products to reduce paper usage. Our leadership has been recognized by the State of Indiana’s prestigious Environmental Stewardship Program, which awarded the Warsaw facility membership for its contributions to continuous environmental improvements and demonstration of long-term compliance with environmenta...